• Amiodarone hydrochloride, a benzofurane derivative used for the treatment of cardiac arrhythmias, is known to cause a verticillate epithelial keratopathy, which
A 50-year-old woman was reported seeing halos
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Patients treated with amiodarone warrant thorough ocular examination yearly to monitor for rare but serious ocular complications
One study found that neurotrophic keratitis was a leading cause of vortex keratopathy
Corneal Whorls Cause Wonder
A 69-year-old black female presented complaining of haloes and glare in both eyes, at distance and near, occurring for the past two
To report a case of amiodarone-induced keratopathy involving the entire cornea, including the endothelium
Other causes of whorl keratopathy include Fabry’s Disease, multiple myeloma, epidemic keratoconjunctivitis, neurotrophic keratitis, or and iron deposition in the cornea
The deposits may cause no symptoms or decrease vision due to clouding or scarring of the cornea
Obtain baseline and periodic liver transaminases and discontinue or reduce dose if the increase exceeds three times normal, or doubles in a patient with an elevated baseline
4 ± 59
0): 124 Other disorders of the eye with mcc or thrombolytic agent
In almost all patients, it causes bilateral vortex keratopathy, described as a pattern of ocher to golden corneal deposits in a vortex configuration
The risk of developing TdP increases in patients with preexisting electrolyte imbalances or those undergoing concurrent treatment with beta-blockers and/or digoxin
The corneal deposits rarely lead to visual loss, but some patients may see halos and colored rings around lights
They do not cause sufficient cell damage to produce staining with fluorescein, nor do they cause Amiodarone may cause heart problems, such as slowing of the heart
Fifteen of the patients (60%) saw halos around lights and/or a decrease in vi sion, and four (16%) reported blurred vision
An unusual case of unilateral amiodarone vortex keratopathy in an elderly woman with corneal dysplasia in the second eye is presented
Slit lamp examination of both eyes of a patient treated for 6 years showed a bilateral, symmetric, whorl-like The Centre for Adverse Reactions Monitoring (CARM) has received 51 reports of eye-related adverse reactions to amiodarone up to April 2011